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The approach will be used for medical services that are commonly subject to prior authorization, such as orthopedic surgeries and imaging services.
FTC reached a settlement with Express Scripts in February and is currently in negotiations with OptumRx.
President and COO Brian Evanko to succeed Cordani as chief executive officer.
CarepathRx supports a range of home and ambulatory infusion solutions to hospitals and health systems, Evernorth says.
The layoffs follow the August acquisition by Sycamore Partners.
Amazon is competing with Walmart in the delivery business and against pharmacies such as CVS and Walgreens.
The reduction represents less than 3% of the company's global workforce.
The company lowered its full-year earnings guidance despite an improving outlook for its medical costs.
A lawsuit alleged Express Scripts' conduct resulted in artificially inflated insulin drug prices.
CEO scheduled to testify before House subcommittee on health insurance affordability.